Drug interactions
Etoposide + Fluconazole
Severity: Moderate
Etoposide and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is metabolized partly by CYP3A4, and azole antifungals may raise its exposure. This may increase myelosuppression and mucositis, though data for fluconazole are limited.
What this interaction means in plain words
Etoposide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, decreasing etoposide clearance.
What to do
Monitor complete blood counts closely during co-administration. Consider etoposide dose reduction if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Fluconazole?
MediHelp rates the interaction as moderate. Etoposide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etoposide is metabolized partly by CYP3A4, and azole antifungals may raise its exposure. This may increase myelosuppression and mucositis, though data for fluconazole are limited.
How serious is the interaction between Etoposide and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during co-administration. Consider etoposide dose reduction if marked myelosuppression occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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