Drug interactions
Etoposide + Ranolazine
Severity: Moderate
Etoposide and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, which transports etoposide, so etoposide absorption may increase and its clearance may fall. This could intensify myelosuppression and gastrointestinal toxicity, although clinical data are lacking.
What this interaction means in plain words
Etoposide and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by ranolazine may increase etoposide absorption and reduce its elimination.
What to do
Monitor complete blood counts closely during etoposide cycles. Reduce the etoposide dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Ranolazine?
MediHelp rates the interaction as moderate. Etoposide and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein, which transports etoposide, so etoposide absorption may increase and its clearance may fall. This could intensify myelosuppression and gastrointestinal toxicity, although clinical data are lacking.
How serious is the interaction between Etoposide and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during etoposide cycles. Reduce the etoposide dose if marked myelosuppression occurs.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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