Drug interactions
Etoposide + Stiripentol
Severity: Moderate
Etoposide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has mixed inhibitory and inducing effects on CYP3A4, and etoposide is partly cleared by this enzyme. Etoposide exposure may therefore rise or fall unpredictably, affecting either toxicity (myelosuppression) or antitumour efficacy. The size of the effect is not well characterised.
What this interaction means in plain words
Etoposide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol both inhibits and induces CYP3A4, altering the metabolic clearance of etoposide in an unpredictable direction.
What to do
Monitor blood counts and clinical response to etoposide when stiripentol is started or stopped. Adjust the etoposide dose if marked toxicity or reduced effect is observed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Etoposide with Stiripentol?
MediHelp rates the interaction as moderate. Etoposide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has mixed inhibitory and inducing effects on CYP3A4, and etoposide is partly cleared by this enzyme. Etoposide exposure may therefore rise or fall unpredictably, affecting either toxicity (myelosuppression) or antitumour efficacy. The size of the effect is not well characterised.
How serious is the interaction between Etoposide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical response to etoposide when stiripentol is started or stopped. Adjust the etoposide dose if marked toxicity or reduced effect is observed.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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