Drug interactions
Etrasimod + Gemcitabine
Severity: Major
Etrasimod and Gemcitabine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes through S1P receptor modulation, and gemcitabine causes myelosuppression. Together they may increase the risk of serious infection. The combination has not been formally studied.
What this interaction means in plain words
Etrasimod and Gemcitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Gemcitabine belongs to Oncology.
Why it happens
Additive immunosuppressive effects: S1P receptor modulation sequesters lymphocytes while gemcitabine suppresses bone marrow function.
What to do
Avoid concurrent use where possible, and consider an alternative to etrasimod during chemotherapy. If unavoidable, monitor complete blood counts and for signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Gemcitabine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Gemcitabine?
MediHelp rates the interaction as major. Etrasimod and Gemcitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes through S1P receptor modulation, and gemcitabine causes myelosuppression. Together they may increase the risk of serious infection. The combination has not been formally studied.
How serious is the interaction between Etrasimod and Gemcitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, and consider an alternative to etrasimod during chemotherapy. If unavoidable, monitor complete blood counts and for signs of infection.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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