Drug interactions
Etrasimod + Hydroxycarbamide
Severity: Major
Etrasimod and Hydroxycarbamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can reduce immune function and etrasimod lowers circulating lymphocytes. Combining them may increase infection risk, and this has not been studied.
What this interaction means in plain words
Etrasimod and Hydroxycarbamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive immunosuppression, with lymphocyte sequestration by etrasimod and myelosuppression by hydroxyurea.
What to do
Avoid concurrent use where possible. If needed, monitor complete blood counts and signs of infection closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Hydroxycarbamide?
MediHelp rates the interaction as major. Etrasimod and Hydroxycarbamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can reduce immune function and etrasimod lowers circulating lymphocytes. Combining them may increase infection risk, and this has not been studied.
How serious is the interaction between Etrasimod and Hydroxycarbamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If needed, monitor complete blood counts and signs of infection closely.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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