Drug interactions
Etrasimod + Labetalol
Severity: Moderate
Etrasimod and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause a transient reduction in heart rate and AV conduction delay when treatment starts. Beta-blockers such as labetalol also slow heart rate and AV conduction, so bradycardia could be amplified, particularly if the beta-blocker is started after etrasimod.
What this interaction means in plain words
Etrasimod and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Labetalol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects through S1P receptor modulation and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG when starting etrasimod in patients on labetalol, and review the need for cardiac monitoring. Take extra care when starting a beta-blocker in a patient already stable on etrasimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etrasimod and Labetalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Labetalol?
MediHelp rates the interaction as moderate. Etrasimod and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can cause a transient reduction in heart rate and AV conduction delay when treatment starts. Beta-blockers such as labetalol also slow heart rate and AV conduction, so bradycardia could be amplified, particularly if the beta-blocker is started after etrasimod.
How serious is the interaction between Etrasimod and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting etrasimod in patients on labetalol, and review the need for cardiac monitoring. Take extra care when starting a beta-blocker in a patient already stable on etrasimod.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
