Drug interactions
Etrasimod + Liposomal doxorubicin
Severity: Moderate
Etrasimod and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and doxorubicin is myelosuppressive and immunosuppressive. Together they may add to the risk of infection, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Liposomal doxorubicin belongs to Oncology.
Why it happens
Additive immunosuppression via S1P receptor-mediated lymphocyte sequestration and cytotoxic marrow suppression.
What to do
Monitor for infection and check blood counts including lymphocytes. Consider whether etrasimod should be withheld during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Etrasimod and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod lowers circulating lymphocytes, and doxorubicin is myelosuppressive and immunosuppressive. Together they may add to the risk of infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check blood counts including lymphocytes. Consider whether etrasimod should be withheld during chemotherapy.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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