Drug interactions
Etrasimod + Losartan
Severity: Minor
Etrasimod and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod exposure rises when moderate to strong CYP2C8 inhibitors are given with CYP2C9 poor metabolizer status. Losartan is not a meaningful CYP2C8 inhibitor, so a relevant interaction is unlikely.
What this interaction means in plain words
Etrasimod and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etrasimod belongs to Gastrointestinal Tract; Losartan belongs to Cardiovascular.
Why it happens
No established mechanism; losartan is not a clinically relevant CYP2C8 or CYP2C9 inhibitor.
What to do
No adjustment needed; monitor heart rate as usual during etrasimod initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Losartan?
MediHelp rates the interaction as minor. Etrasimod and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod exposure rises when moderate to strong CYP2C8 inhibitors are given with CYP2C9 poor metabolizer status. Losartan is not a meaningful CYP2C8 inhibitor, so a relevant interaction is unlikely.
How serious is the interaction between Etrasimod and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor heart rate as usual during etrasimod initiation.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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