Drug interactions
Etrasimod + Metoprolol
Severity: Moderate
Etrasimod and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and AV conduction on initiation. Combining with a beta-blocker could add to bradycardia or conduction delay.
What this interaction means in plain words
Etrasimod and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Metoprolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects.
What to do
Obtain baseline ECG and monitor heart rate when starting etrasimod in patients on metoprolol; seek cardiology advice if conduction disease is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Metoprolol?
MediHelp rates the interaction as moderate. Etrasimod and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and AV conduction on initiation. Combining with a beta-blocker could add to bradycardia or conduction delay.
How serious is the interaction between Etrasimod and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and monitor heart rate when starting etrasimod in patients on metoprolol; seek cardiology advice if conduction disease is present.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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