Drug interactions
Etrasimod + Moxifloxacin
Severity: Moderate
Etrasimod and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient slowing of heart rate and AV conduction delay on initiation. Bradycardia is a risk factor for torsades de pointes with QT-prolonging drugs such as moxifloxacin.
What this interaction means in plain words
Etrasimod and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic effect: S1P receptor-mediated bradycardia combined with moxifloxacin QT prolongation.
What to do
Obtain a baseline ECG before starting etrasimod and consider cardiac monitoring at initiation. Consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Moxifloxacin?
MediHelp rates the interaction as moderate. Etrasimod and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can cause transient slowing of heart rate and AV conduction delay on initiation. Bradycardia is a risk factor for torsades de pointes with QT-prolonging drugs such as moxifloxacin.
How serious is the interaction between Etrasimod and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod and consider cardiac monitoring at initiation. Consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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