Drug interactions
Etrasimod + Mycophenolate mofetil
Severity: Major
Etrasimod and Mycophenolate mofetil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes, and combining it with mycophenolate may add to immunosuppression and infection risk. The combination has not been studied.
What this interaction means in plain words
Etrasimod and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Additive immunosuppression: S1P receptor modulation sequesters lymphocytes while mycophenolate inhibits lymphocyte proliferation.
What to do
Avoid combining; if unavoidable, monitor lymphocyte counts and signs of infection closely. Immune effects of etrasimod may persist for weeks after stopping.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Mycophenolate mofetil?
MediHelp rates the interaction as major. Etrasimod and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes, and combining it with mycophenolate may add to immunosuppression and infection risk. The combination has not been studied.
How serious is the interaction between Etrasimod and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; if unavoidable, monitor lymphocyte counts and signs of infection closely. Immune effects of etrasimod may persist for weeks after stopping.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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