Drug interactions
Etrasimod + Paliperidone
Severity: Moderate
Etrasimod and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and delay AV conduction on initiation, and paliperidone prolongs the QT interval. Bradycardia combined with QT prolongation may raise the risk of torsades de pointes.
What this interaction means in plain words
Etrasimod and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Paliperidone belongs to Central Nervous System.
Why it happens
Additive effects of S1P-receptor-mediated bradycardia and paliperidone-associated QT prolongation.
What to do
Obtain a baseline ECG before starting etrasimod and consider cardiology advice in patients on QT-prolonging drugs. Monitor heart rate and ECG after initiation and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Paliperidone?
MediHelp rates the interaction as moderate. Etrasimod and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and delay AV conduction on initiation, and paliperidone prolongs the QT interval. Bradycardia combined with QT prolongation may raise the risk of torsades de pointes.
How serious is the interaction between Etrasimod and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod and consider cardiology advice in patients on QT-prolonging drugs. Monitor heart rate and ECG after initiation and correct electrolyte abnormalities.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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