Drug interactions
Etrasimod + Tacrolimus
Severity: Major
Etrasimod and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is an S1P receptor modulator that lowers circulating lymphocytes, and tacrolimus is also immunosuppressive. Used together they may add to immunosuppression and infection risk, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression from S1P receptor modulation with lymphocyte sequestration plus calcineurin inhibition.
What to do
Avoid the combination where possible, including for several weeks after etrasimod is stopped. If used, monitor for infection and check the lymphocyte count.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Tacrolimus?
MediHelp rates the interaction as major. Etrasimod and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod is an S1P receptor modulator that lowers circulating lymphocytes, and tacrolimus is also immunosuppressive. Used together they may add to immunosuppression and infection risk, and the combination has not been studied.
How serious is the interaction between Etrasimod and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, including for several weeks after etrasimod is stopped. If used, monitor for infection and check the lymphocyte count.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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