Drug interactions
Etravirine + Ibuprofen
Severity: Minor
Etravirine and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 and CYP2C19 in vitro and may modestly raise levels of CYP2C9 substrates such as ibuprofen. Clinical significance is likely small.
What this interaction means in plain words
Etravirine and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Ibuprofen belongs to Musculoskeletal.
Why it happens
Etravirine inhibition of CYP2C9 may reduce ibuprofen clearance.
What to do
No routine adjustment is needed; use the lowest effective ibuprofen dose and monitor for NSAID adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ibuprofen?
MediHelp rates the interaction as minor. Etravirine and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine inhibits CYP2C9 and CYP2C19 in vitro and may modestly raise levels of CYP2C9 substrates such as ibuprofen. Clinical significance is likely small.
How serious is the interaction between Etravirine and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; use the lowest effective ibuprofen dose and monitor for NSAID adverse effects.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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