Drug interactions
Etravirine + Irinotecan
Severity: Moderate
Etravirine and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest CYP3A4 inducer and may lower exposure to irinotecan and its active metabolite SN-38. Reduced exposure could blunt antitumour effect, although the clinical impact is not well characterised.
What this interaction means in plain words
Etravirine and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Irinotecan belongs to Oncology.
Why it happens
Induction of CYP3A4 increases oxidative clearance of irinotecan to inactive metabolites.
What to do
Prefer an antiretroviral regimen without enzyme-inducing effects where possible. If combined, monitor tumour response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Irinotecan?
MediHelp rates the interaction as moderate. Etravirine and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a modest CYP3A4 inducer and may lower exposure to irinotecan and its active metabolite SN-38. Reduced exposure could blunt antitumour effect, although the clinical impact is not well characterised.
How serious is the interaction between Etravirine and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiretroviral regimen without enzyme-inducing effects where possible. If combined, monitor tumour response and toxicity.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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