Drug interactions
Etravirine + Isosorbide dinitrate
Severity: Minor
Etravirine and Isosorbide dinitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4, but isosorbide dinitrate is metabolized mostly by other routes. Reduced nitrate effect is unlikely to be significant.
What this interaction means in plain words
Etravirine and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Isosorbide dinitrate belongs to Cardiovascular.
Why it happens
Etravirine induces CYP3A4, a minor pathway for dinitrate.
What to do
No adjustment is needed. Reassess anginal control if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Isosorbide dinitrate?
MediHelp rates the interaction as minor. Etravirine and Isosorbide dinitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine induces CYP3A4, but isosorbide dinitrate is metabolized mostly by other routes. Reduced nitrate effect is unlikely to be significant.
How serious is the interaction between Etravirine and Isosorbide dinitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Reassess anginal control if symptoms worsen.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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