Drug interactions
Etravirine + Ketoconazole
Severity: Moderate
Etravirine and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise etravirine concentrations, while etravirine may lower ketoconazole concentrations. Clinical consequences are usually modest and manageable.
What this interaction means in plain words
Etravirine and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4 and CYP2C metabolism of etravirine, while etravirine is a modest CYP3A4 inducer that can lower ketoconazole levels.
What to do
No empiric etravirine dose change is usually needed. Monitor antifungal response and adjust ketoconazole if efficacy is inadequate, taking into account other antiretrovirals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ketoconazole?
MediHelp rates the interaction as moderate. Etravirine and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may raise etravirine concentrations, while etravirine may lower ketoconazole concentrations. Clinical consequences are usually modest and manageable.
How serious is the interaction between Etravirine and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric etravirine dose change is usually needed. Monitor antifungal response and adjust ketoconazole if efficacy is inadequate, taking into account other antiretrovirals.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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