Drug interactions
Etravirine + Meloxicam
Severity: Minor
Etravirine and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 and CYP2C19 while also inducing CYP3A4, so its net effect on meloxicam is uncertain. Exposure could rise because CYP2C9 is the principal pathway.
What this interaction means in plain words
Etravirine and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Meloxicam belongs to Musculoskeletal.
Why it happens
Etravirine inhibition of CYP2C9 may reduce meloxicam clearance, partly offset by CYP3A4 induction.
What to do
Monitor for NSAID adverse effects such as GI upset and fluid retention, and use the lowest effective meloxicam dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Meloxicam?
MediHelp rates the interaction as minor. Etravirine and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine inhibits CYP2C9 and CYP2C19 while also inducing CYP3A4, so its net effect on meloxicam is uncertain. Exposure could rise because CYP2C9 is the principal pathway.
How serious is the interaction between Etravirine and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as GI upset and fluid retention, and use the lowest effective meloxicam dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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