Drug interactions
Etravirine + Metformin-repaglinide
Severity: Moderate
Etravirine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and CYP2C9 and may lower repaglinide levels, which can weaken glycemic control. The effect is generally modest.
What this interaction means in plain words
Etravirine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Metformin-repaglinide belongs to Endocrine.
Why it happens
Induction of CYP3A4 by etravirine increases repaglinide metabolism.
What to do
Monitor blood glucose after starting or stopping etravirine and titrate the repaglinide dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Etravirine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and CYP2C9 and may lower repaglinide levels, which can weaken glycemic control. The effect is generally modest.
How serious is the interaction between Etravirine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping etravirine and titrate the repaglinide dose to response.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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