Drug interactions
Etravirine + Methadone
Severity: Moderate
Etravirine and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is an inducer of CYP3A4 and may lower methadone concentrations, though the effect on methadone exposure in studies has been small. Some patients could still develop withdrawal symptoms.
What this interaction means in plain words
Etravirine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Methadone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 and CYP2B6-mediated methadone metabolism, which may modestly reduce methadone levels.
What to do
Monitor for opioid withdrawal symptoms or reduced effect after starting etravirine. Increase the methadone dose if clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Methadone?
MediHelp rates the interaction as moderate. Etravirine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is an inducer of CYP3A4 and may lower methadone concentrations, though the effect on methadone exposure in studies has been small. Some patients could still develop withdrawal symptoms.
How serious is the interaction between Etravirine and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for opioid withdrawal symptoms or reduced effect after starting etravirine. Increase the methadone dose if clinically needed.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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