Drug interactions
Etravirine + Nateglinide
Severity: Moderate
Etravirine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C9 and CYP2C19 and induces CYP3A4, so it may raise nateglinide exposure through reduced CYP2C9 clearance. This could increase hypoglycemia risk. The effect of nateglinide on etravirine is unlikely to matter clinically.
What this interaction means in plain words
Etravirine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Nateglinide belongs to Endocrine.
Why it happens
Etravirine inhibition of CYP2C9-mediated nateglinide metabolism, partly offset by CYP3A4 induction.
What to do
Monitor blood glucose for hypoglycemia after starting etravirine. Reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Nateglinide?
MediHelp rates the interaction as moderate. Etravirine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine inhibits CYP2C9 and CYP2C19 and induces CYP3A4, so it may raise nateglinide exposure through reduced CYP2C9 clearance. This could increase hypoglycemia risk. The effect of nateglinide on etravirine is unlikely to matter clinically.
How serious is the interaction between Etravirine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose for hypoglycemia after starting etravirine. Reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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