Drug interactions
Etravirine + Nifedipine
Severity: Moderate
Etravirine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and can lower nifedipine concentrations, reducing blood pressure or angina control. Effects on etravirine from nifedipine are minimal.
What this interaction means in plain words
Etravirine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Nifedipine belongs to Cardiovascular.
Why it happens
Etravirine induces CYP3A4, increasing nifedipine clearance.
What to do
Monitor blood pressure and titrate nifedipine upward as needed when etravirine is started; reduce again if etravirine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Nifedipine?
MediHelp rates the interaction as moderate. Etravirine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and can lower nifedipine concentrations, reducing blood pressure or angina control. Effects on etravirine from nifedipine are minimal.
How serious is the interaction between Etravirine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nifedipine upward as needed when etravirine is started; reduce again if etravirine is stopped.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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