Drug interactions
Etravirine + Pantoprazole
Severity: Minor
Etravirine and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP2C19 and also inhibits it, so pantoprazole levels may change in either direction. Etravirine's own exposure is not meaningfully reduced by PPIs.
What this interaction means in plain words
Etravirine and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Etravirine modulates CYP2C19 activity, altering pantoprazole metabolism.
What to do
No routine adjustment is needed. Monitor acid-suppression response and adjust the pantoprazole dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Pantoprazole?
MediHelp rates the interaction as minor. Etravirine and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine induces CYP2C19 and also inhibits it, so pantoprazole levels may change in either direction. Etravirine's own exposure is not meaningfully reduced by PPIs.
How serious is the interaction between Etravirine and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor acid-suppression response and adjust the pantoprazole dose if control is inadequate.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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