Drug interactions
Etravirine + Pazopanib
Severity: Moderate
Etravirine and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may reduce pazopanib exposure, potentially lowering its antitumor efficacy. The magnitude is not well characterized.
What this interaction means in plain words
Etravirine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Pazopanib belongs to Oncology.
Why it happens
CYP3A4 induction by etravirine increases pazopanib clearance.
What to do
Consider an antiretroviral regimen without CYP3A4 induction if feasible. Monitor tumor response and pazopanib effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Pazopanib?
MediHelp rates the interaction as moderate. Etravirine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may reduce pazopanib exposure, potentially lowering its antitumor efficacy. The magnitude is not well characterized.
How serious is the interaction between Etravirine and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antiretroviral regimen without CYP3A4 induction if feasible. Monitor tumor response and pazopanib effects.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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