Drug interactions
Etravirine + Pioglitazone
Severity: Minor
Etravirine and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest inducer of CYP3A4 and may slightly reduce exposure to drugs partly cleared by that enzyme. Pioglitazone is metabolized mainly by CYP2C8 with a smaller CYP3A4 contribution, so a meaningful loss of glycemic effect is unlikely.
What this interaction means in plain words
Etravirine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Pioglitazone belongs to Endocrine.
Why it happens
Etravirine induction of CYP3A4 may modestly increase pioglitazone metabolism.
What to do
No dose change is usually needed; check glycemic control (glucose, HbA1c) if therapy is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Pioglitazone?
MediHelp rates the interaction as minor. Etravirine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a modest inducer of CYP3A4 and may slightly reduce exposure to drugs partly cleared by that enzyme. Pioglitazone is metabolized mainly by CYP2C8 with a smaller CYP3A4 contribution, so a meaningful loss of glycemic effect is unlikely.
How serious is the interaction between Etravirine and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; check glycemic control (glucose, HbA1c) if therapy is started or stopped.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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