Drug interactions
Etravirine + Praziquantel
Severity: Moderate
Etravirine and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine may reduce praziquantel exposure, risking treatment failure. The effect is predicted from enzyme induction and is less pronounced than with rifampin.
What this interaction means in plain words
Etravirine and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Praziquantel belongs to Anti Parasitic.
Why it happens
Etravirine induces CYP3A4, increasing praziquantel clearance.
What to do
Monitor for parasitological cure and consider a higher praziquantel dose or retreatment if response is inadequate; stopping etravirine is generally not practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Praziquantel?
MediHelp rates the interaction as moderate. Etravirine and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine may reduce praziquantel exposure, risking treatment failure. The effect is predicted from enzyme induction and is less pronounced than with rifampin.
How serious is the interaction between Etravirine and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for parasitological cure and consider a higher praziquantel dose or retreatment if response is inadequate; stopping etravirine is generally not practical.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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