Drug interactions
Etravirine + Sofosbuvir-velpatasvir
Severity: Moderate
Etravirine and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a moderate inducer of CYP3A4 and may lower velpatasvir exposure. Reduced antiviral levels could compromise hepatitis C cure.
What this interaction means in plain words
Etravirine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 (and CYP2C enzymes), increasing velpatasvir metabolism.
What to do
Labeling does not require avoidance. Monitor HCV virologic response, or consider an alternative HIV or HCV regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Etravirine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a moderate inducer of CYP3A4 and may lower velpatasvir exposure. Reduced antiviral levels could compromise hepatitis C cure.
How serious is the interaction between Etravirine and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling does not require avoidance. Monitor HCV virologic response, or consider an alternative HIV or HCV regimen.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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