Drug interactions
Etravirine + Sorafenib
Severity: Moderate
Etravirine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower sorafenib concentrations. Reduced exposure may weaken antitumor effect, though sorafenib is only partly dependent on CYP3A4.
What this interaction means in plain words
Etravirine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Etravirine induces CYP3A4, increasing sorafenib metabolism.
What to do
Monitor for reduced response to sorafenib. Consider an alternative antiretroviral without inducing effects if loss of efficacy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Sorafenib?
MediHelp rates the interaction as moderate. Etravirine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower sorafenib concentrations. Reduced exposure may weaken antitumor effect, though sorafenib is only partly dependent on CYP3A4.
How serious is the interaction between Etravirine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to sorafenib. Consider an alternative antiretroviral without inducing effects if loss of efficacy is suspected.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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