Drug interactions
Etravirine + Tolterodine
Severity: Minor
Etravirine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4, which may lower tolterodine concentrations and reduce its effect on bladder symptoms. Impact is limited because CYP2D6 provides the main clearance pathway and the active 5-hydroxymethyl metabolite is formed by CYP2D6.
What this interaction means in plain words
Etravirine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Tolterodine belongs to Genitourinary.
Why it happens
CYP3A4 induction by etravirine increases tolterodine clearance.
What to do
Monitor symptom control for reduced efficacy and adjust tolterodine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Tolterodine?
MediHelp rates the interaction as minor. Etravirine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine induces CYP3A4, which may lower tolterodine concentrations and reduce its effect on bladder symptoms. Impact is limited because CYP2D6 provides the main clearance pathway and the active 5-hydroxymethyl metabolite is formed by CYP2D6.
How serious is the interaction between Etravirine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control for reduced efficacy and adjust tolterodine dose if needed.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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