Drug interactions
Everolimus + Fexinidazole
Severity: Moderate
Everolimus and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise everolimus concentrations. This could increase toxicity, including myelosuppression, stomatitis and infection.
What this interaction means in plain words
Everolimus and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of everolimus by fexinidazole.
What to do
Monitor for everolimus toxicity and check trough levels in transplant patients, reducing the dose if concentrations or adverse effects are high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Fexinidazole?
MediHelp rates the interaction as moderate. Everolimus and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise everolimus concentrations. This could increase toxicity, including myelosuppression, stomatitis and infection.
How serious is the interaction between Everolimus and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity and check trough levels in transplant patients, reducing the dose if concentrations or adverse effects are high.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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