Drug interactions
Everolimus + Haemophilus influenzae type b vaccine
Severity: Moderate
Everolimus and Haemophilus influenzae type b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus-related immunosuppression may reduce the antibody response to the Hib vaccine, leaving incomplete protection.
What this interaction means in plain words
Everolimus and Haemophilus influenzae type b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition impairs lymphocyte proliferation and vaccine response.
What to do
Vaccinate before starting everolimus where possible; if given during therapy, consider revaccination after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Haemophilus influenzae type b vaccine?
MediHelp rates the interaction as moderate. Everolimus and Haemophilus influenzae type b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus-related immunosuppression may reduce the antibody response to the Hib vaccine, leaving incomplete protection.
How serious is the interaction between Everolimus and Haemophilus influenzae type b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting everolimus where possible; if given during therapy, consider revaccination after immune recovery.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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