Drug interactions
Everolimus + Hepatitis b vaccine
Severity: Moderate
Everolimus and Hepatitis b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus-related immunosuppression can lower seroconversion and antibody titers after hepatitis B vaccination. The vaccine is non-live and not an infection risk, but protection may be inadequate.
What this interaction means in plain words
Everolimus and Hepatitis b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition reduces lymphocyte proliferation and humoral response to vaccine antigens.
What to do
Vaccinate before starting everolimus when feasible. Measure anti-HBs titers after the series and give booster or higher-dose regimens if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Everolimus and Hepatitis b vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Hepatitis b vaccine?
MediHelp rates the interaction as moderate. Everolimus and Hepatitis b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus-related immunosuppression can lower seroconversion and antibody titers after hepatitis B vaccination. The vaccine is non-live and not an infection risk, but protection may be inadequate.
How serious is the interaction between Everolimus and Hepatitis b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting everolimus when feasible. Measure anti-HBs titers after the series and give booster or higher-dose regimens if response is inadequate.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
