Drug interactions
Everolimus + Human papillomavirus vaccine nonavalent
Severity: Moderate
Everolimus and Human papillomavirus vaccine nonavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is immunosuppressive and may blunt the antibody response to the HPV vaccine, leaving the patient less protected. The vaccine is not a live vaccine, so it is not unsafe, but its effectiveness may be reduced.
What this interaction means in plain words
Everolimus and Human papillomavirus vaccine nonavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation and so weakens the immune response to vaccine antigens.
What to do
Where possible, complete vaccination before starting everolimus. If the patient is already on therapy, vaccinate as indicated and consider checking antibody response, since a reduced response is likely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Human papillomavirus vaccine nonavalent?
MediHelp rates the interaction as moderate. Everolimus and Human papillomavirus vaccine nonavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus is immunosuppressive and may blunt the antibody response to the HPV vaccine, leaving the patient less protected. The vaccine is not a live vaccine, so it is not unsafe, but its effectiveness may be reduced.
How serious is the interaction between Everolimus and Human papillomavirus vaccine nonavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, complete vaccination before starting everolimus. If the patient is already on therapy, vaccinate as indicated and consider checking antibody response, since a reduced response is likely.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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