Drug interactions
Everolimus + Human papillomavirus vaccine quadrivalent
Severity: Moderate
Everolimus and Human papillomavirus vaccine quadrivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is immunosuppressive and may reduce the antibody response to the quadrivalent HPV vaccine, giving less protection. The vaccine is non-live and can be given, but its effect may be diminished.
What this interaction means in plain words
Everolimus and Human papillomavirus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation and so weakens the immune response to vaccine antigens.
What to do
Give the vaccine series before starting everolimus when feasible. If already on treatment, vaccinate as recommended and consider serologic confirmation of response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Human papillomavirus vaccine quadrivalent?
MediHelp rates the interaction as moderate. Everolimus and Human papillomavirus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus is immunosuppressive and may reduce the antibody response to the quadrivalent HPV vaccine, giving less protection. The vaccine is non-live and can be given, but its effect may be diminished.
How serious is the interaction between Everolimus and Human papillomavirus vaccine quadrivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine series before starting everolimus when feasible. If already on treatment, vaccinate as recommended and consider serologic confirmation of response.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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