Drug interactions
Everolimus + Hydrocortisone
Severity: Minor
Everolimus and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is only a weak potential CYP3A4 inducer, so a meaningful fall in everolimus levels is unlikely. Both drugs are often used together in transplant regimens, where additive immunosuppression is the more relevant consideration.
What this interaction means in plain words
Everolimus and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 induction by hydrocortisone; additive immunosuppression is the main pharmacodynamic effect.
What to do
Monitor everolimus trough concentrations as per routine transplant practice and adjust the dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Hydrocortisone?
MediHelp rates the interaction as minor. Everolimus and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is only a weak potential CYP3A4 inducer, so a meaningful fall in everolimus levels is unlikely. Both drugs are often used together in transplant regimens, where additive immunosuppression is the more relevant consideration.
How serious is the interaction between Everolimus and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations as per routine transplant practice and adjust the dose accordingly.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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