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Drug interactions

Everolimus + Influenza virus vaccine quadrivalent

Severity: Minor

Everolimus and Influenza virus vaccine quadrivalent: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Everolimus may reduce antibody response to inactivated influenza vaccine. The vaccine remains recommended in immunosuppressed patients because the benefit outweighs the diminished response.

What this interaction means in plain words

Everolimus and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Evidence level: Moderate

Why it happens

mTOR inhibition dampens lymphocyte proliferation and vaccine-induced antibody production.

What to do

Give the inactivated vaccine as scheduled without interrupting everolimus. Reinforce other preventive measures during influenza season.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Everolimus with Influenza virus vaccine quadrivalent?

MediHelp rates the interaction as minor. Everolimus and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Everolimus may reduce antibody response to inactivated influenza vaccine. The vaccine remains recommended in immunosuppressed patients because the benefit outweighs the diminished response.

How serious is the interaction between Everolimus and Influenza virus vaccine quadrivalent?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine as scheduled without interrupting everolimus. Reinforce other preventive measures during influenza season.

What other medicines interact with Everolimus?

MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.

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