Drug interactions
Everolimus + Influenza virus vaccine trivalent recombinant
Severity: Moderate
Everolimus and Influenza virus vaccine trivalent recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is an immunosuppressant and can blunt the antibody response to vaccination. The recombinant vaccine is non-live and safe to give, but protection may be less than in immunocompetent patients.
What this interaction means in plain words
Everolimus and Influenza virus vaccine trivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation and reduces the vaccine immune response.
What to do
Vaccinate as recommended, ideally before starting everolimus when feasible, and do not withhold the non-live vaccine. Remain alert for influenza despite vaccination and consider other preventive measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Influenza virus vaccine trivalent recombinant?
MediHelp rates the interaction as moderate. Everolimus and Influenza virus vaccine trivalent recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus is an immunosuppressant and can blunt the antibody response to vaccination. The recombinant vaccine is non-live and safe to give, but protection may be less than in immunocompetent patients.
How serious is the interaction between Everolimus and Influenza virus vaccine trivalent recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as recommended, ideally before starting everolimus when feasible, and do not withhold the non-live vaccine. Remain alert for influenza despite vaccination and consider other preventive measures.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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