Drug interactions
Everolimus + Japanese encephalitis virus vaccine
Severity: Moderate
Everolimus and Japanese encephalitis virus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Available Japanese encephalitis vaccines are generally inactivated, so the main concern is a weaker immune response in a patient on everolimus. This matters for travelers to endemic areas who may be left under-protected.
What this interaction means in plain words
Everolimus and Japanese encephalitis virus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition reduces lymphocyte proliferation and vaccine-induced immune response.
What to do
Vaccinate well before travel and ideally before everolimus is started. Consider checking antibody response and reinforce mosquito-avoidance measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Japanese encephalitis virus vaccine?
MediHelp rates the interaction as moderate. Everolimus and Japanese encephalitis virus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Available Japanese encephalitis vaccines are generally inactivated, so the main concern is a weaker immune response in a patient on everolimus. This matters for travelers to endemic areas who may be left under-protected.
How serious is the interaction between Everolimus and Japanese encephalitis virus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate well before travel and ideally before everolimus is started. Consider checking antibody response and reinforce mosquito-avoidance measures.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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