Drug interactions
Everolimus + Mercaptopurine
Severity: Moderate
Everolimus and Mercaptopurine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune responses, so together they increase susceptibility to bacterial, viral and opportunistic infections. Myelosuppression may also be more pronounced.
What this interaction means in plain words
Everolimus and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Mercaptopurine belongs to Oncology.
Why it happens
Additive immunosuppression via mTOR inhibition and thiopurine inhibition of lymphocyte proliferation.
What to do
Monitor for infection and check complete blood counts periodically. Adjust doses of either drug if cytopenias or infections develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Mercaptopurine?
MediHelp rates the interaction as moderate. Everolimus and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress immune responses, so together they increase susceptibility to bacterial, viral and opportunistic infections. Myelosuppression may also be more pronounced.
How serious is the interaction between Everolimus and Mercaptopurine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check complete blood counts periodically. Adjust doses of either drug if cytopenias or infections develop.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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