Drug interactions
Everolimus + Metformin-sitagliptin
Severity: Moderate
Everolimus and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus commonly causes hyperglycemia and hyperlipidemia, which can work against the glucose-lowering action of antidiabetic therapy. Patients with diabetes may need intensification of their treatment while on everolimus.
What this interaction means in plain words
Everolimus and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Metformin-sitagliptin belongs to Endocrine.
Why it happens
mTOR inhibition by everolimus induces insulin resistance and reduces pancreatic beta-cell function, opposing the glucose-lowering effect of metformin and sitagliptin.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during everolimus therapy, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Everolimus and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus commonly causes hyperglycemia and hyperlipidemia, which can work against the glucose-lowering action of antidiabetic therapy. Patients with diabetes may need intensification of their treatment while on everolimus.
How serious is the interaction between Everolimus and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during everolimus therapy, and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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