Drug interactions
Everolimus + Metformin
Severity: Moderate
Everolimus and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus commonly causes hyperglycemia and hyperlipidemia through mTOR inhibition, which affects insulin signaling. This can worsen glycemic control in patients taking metformin and may require more intensive treatment.
What this interaction means in plain words
Everolimus and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: mTOR inhibition causes insulin resistance and reduced insulin secretion.
What to do
Monitor fasting glucose before and during everolimus therapy and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Metformin?
MediHelp rates the interaction as moderate. Everolimus and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus commonly causes hyperglycemia and hyperlipidemia through mTOR inhibition, which affects insulin signaling. This can worsen glycemic control in patients taking metformin and may require more intensive treatment.
How serious is the interaction between Everolimus and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose before and during everolimus therapy and intensify antidiabetic treatment as needed.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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