Drug interactions
Everolimus + Metronidazole
Severity: Minor
Everolimus and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is at most a weak CYP3A4 inhibitor, so any rise in everolimus exposure is expected to be small. The clinical significance is uncertain, but everolimus has a narrow therapeutic window and higher levels could increase immunosuppression, stomatitis and metabolic adverse effects.
What this interaction means in plain words
Everolimus and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP3A4-mediated everolimus metabolism by metronidazole; the effect is not well established.
What to do
No empirical dose change is needed; if the two are used together, check everolimus trough concentrations and watch for mucositis or other toxicity during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Metronidazole?
MediHelp rates the interaction as minor. Everolimus and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is at most a weak CYP3A4 inhibitor, so any rise in everolimus exposure is expected to be small. The clinical significance is uncertain, but everolimus has a narrow therapeutic window and higher levels could increase immunosuppression, stomatitis and metabolic adverse effects.
How serious is the interaction between Everolimus and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; if the two are used together, check everolimus trough concentrations and watch for mucositis or other toxicity during the antibiotic course.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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