Drug interactions
Everolimus + Mobocertinib
Severity: Moderate
Everolimus and Mobocertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a moderate CYP3A inducer and may reduce everolimus levels, potentially compromising efficacy. Mobocertinib also carries QT-prolonging risk, which is not shared by everolimus.
What this interaction means in plain words
Everolimus and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mobocertinib induces CYP3A4, increasing everolimus metabolism.
What to do
Monitor everolimus trough concentrations and clinical response, and increase the everolimus dose if levels are subtherapeutic. Prefer an alternative if one is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Mobocertinib?
MediHelp rates the interaction as moderate. Everolimus and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mobocertinib is a moderate CYP3A inducer and may reduce everolimus levels, potentially compromising efficacy. Mobocertinib also carries QT-prolonging risk, which is not shared by everolimus.
How serious is the interaction between Everolimus and Mobocertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and clinical response, and increase the everolimus dose if levels are subtherapeutic. Prefer an alternative if one is available.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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