Drug interactions
Everolimus + Muromonab cd3
Severity: Major
Everolimus and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining everolimus with muromonab-CD3 produces additive immunosuppression and raises the risk of serious infections and lymphoproliferative disorders. Muromonab-CD3 is also a potent T-cell depleting agent used for acute rejection.
What this interaction means in plain words
Everolimus and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic immunosuppression through mTOR inhibition and T-cell depletion.
What to do
Use only when clinically required and under specialist transplant supervision, with reduced baseline immunosuppression as appropriate. Monitor closely for infection and use antimicrobial prophylaxis per protocol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Muromonab cd3?
MediHelp rates the interaction as major. Everolimus and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining everolimus with muromonab-CD3 produces additive immunosuppression and raises the risk of serious infections and lymphoproliferative disorders. Muromonab-CD3 is also a potent T-cell depleting agent used for acute rejection.
How serious is the interaction between Everolimus and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when clinically required and under specialist transplant supervision, with reduced baseline immunosuppression as appropriate. Monitor closely for infection and use antimicrobial prophylaxis per protocol.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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