Drug interactions
Everolimus + Mycophenolate
Severity: Moderate
Everolimus and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus and mycophenolate are both used in transplant immunosuppression regimens and together increase infection and malignancy risk, as well as cytopenias and gastrointestinal effects. Dosing is intentionally managed in combination regimens.
What this interaction means in plain words
Everolimus and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression via mTOR inhibition and inhibition of inosine monophosphate dehydrogenase in lymphocytes.
What to do
The combination is used in practice with dose adjustment, often with reduced calcineurin inhibitor exposure. Monitor blood counts, everolimus trough levels and signs of infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Mycophenolate?
MediHelp rates the interaction as moderate. Everolimus and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus and mycophenolate are both used in transplant immunosuppression regimens and together increase infection and malignancy risk, as well as cytopenias and gastrointestinal effects. Dosing is intentionally managed in combination regimens.
How serious is the interaction between Everolimus and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination is used in practice with dose adjustment, often with reduced calcineurin inhibitor exposure. Monitor blood counts, everolimus trough levels and signs of infection.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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