Drug interactions
Everolimus + Nafcillin
Severity: Moderate
Everolimus and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower everolimus concentrations, reducing efficacy or graft protection. The effect is documented mainly with other drugs, but induction by nafcillin is well described.
What this interaction means in plain words
Everolimus and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 (and possibly P-glycoprotein) by nafcillin increases everolimus clearance.
What to do
Monitor everolimus trough levels and adjust the dose during and after nafcillin therapy. Use an alternative antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Nafcillin?
MediHelp rates the interaction as moderate. Everolimus and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower everolimus concentrations, reducing efficacy or graft protection. The effect is documented mainly with other drugs, but induction by nafcillin is well described.
How serious is the interaction between Everolimus and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and adjust the dose during and after nafcillin therapy. Use an alternative antibiotic when feasible.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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