Drug interactions
Everolimus + Pentobarbital
Severity: Major
Everolimus and Pentobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is an enzyme inducer and may reduce everolimus concentrations, potentially causing loss of efficacy such as graft rejection. The inductive effect develops over days and fades after discontinuation.
What this interaction means in plain words
Everolimus and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturates induce CYP3A4, increasing everolimus metabolism.
What to do
Avoid long-term combination and prefer a non-inducing alternative. If it is necessary, monitor everolimus trough levels and increase the dose as required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Pentobarbital?
MediHelp rates the interaction as major. Everolimus and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentobarbital is an enzyme inducer and may reduce everolimus concentrations, potentially causing loss of efficacy such as graft rejection. The inductive effect develops over days and fades after discontinuation.
How serious is the interaction between Everolimus and Pentobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination and prefer a non-inducing alternative. If it is necessary, monitor everolimus trough levels and increase the dose as required.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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