Drug interactions
Everolimus + Perindopril
Severity: Major
Everolimus and Perindopril: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors such as everolimus raise the risk of angioedema in patients taking ACE inhibitors. Swelling of the face, lips, tongue or airway may occur and can be life-threatening.
What this interaction means in plain words
Everolimus and Perindopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Everolimus belongs to Oncology; Perindopril belongs to Cardiovascular.
Why it happens
Both impair bradykinin breakdown or increase its effects, with mTOR inhibition adding to ACE inhibitor-related bradykinin accumulation.
What to do
Prefer a non-ACE-inhibitor antihypertensive where possible. If combined, counsel patients to seek urgent care for swelling and stop perindopril if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Perindopril?
MediHelp rates the interaction as major. Everolimus and Perindopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. mTOR inhibitors such as everolimus raise the risk of angioedema in patients taking ACE inhibitors. Swelling of the face, lips, tongue or airway may occur and can be life-threatening.
How serious is the interaction between Everolimus and Perindopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-ACE-inhibitor antihypertensive where possible. If combined, counsel patients to seek urgent care for swelling and stop perindopril if angioedema occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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