Drug interactions
Everolimus + Quinapril
Severity: Major
Everolimus and Quinapril: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors such as everolimus combined with ACE inhibitors increase the risk of angioedema. Reactions can involve the face, lips, tongue or airway and may be serious.
What this interaction means in plain words
Everolimus and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive impairment of bradykinin breakdown, as ACE inhibition combines with mTOR inhibitor effects on angioedema pathways.
What to do
Counsel patients to seek urgent care for swelling of the face, lips, tongue or throat. Consider an alternative antihypertensive class, such as a calcium channel blocker, if angioedema occurs or risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Quinapril?
MediHelp rates the interaction as major. Everolimus and Quinapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. mTOR inhibitors such as everolimus combined with ACE inhibitors increase the risk of angioedema. Reactions can involve the face, lips, tongue or airway and may be serious.
How serious is the interaction between Everolimus and Quinapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the face, lips, tongue or throat. Consider an alternative antihypertensive class, such as a calcium channel blocker, if angioedema occurs or risk is high.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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