Drug interactions
Everolimus + Rotavirus oral vaccine live
Severity: Contraindicated
Everolimus and Rotavirus oral vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is immunosuppressive and may blunt the immune response to vaccines. Live vaccine strains can also replicate unchecked and cause disseminated vaccine-strain infection in immunosuppressed patients.
What this interaction means in plain words
Everolimus and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression by mTOR inhibition impairs vaccine-induced immunity and allows replication of live attenuated organisms.
What to do
Avoid live vaccines during everolimus therapy, and complete required vaccinations before starting treatment where feasible. Follow current immunization guidance on the interval after stopping everolimus.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Everolimus and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Everolimus is immunosuppressive and may blunt the immune response to vaccines. Live vaccine strains can also replicate unchecked and cause disseminated vaccine-strain infection in immunosuppressed patients.
How serious is the interaction between Everolimus and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during everolimus therapy, and complete required vaccinations before starting treatment where feasible. Follow current immunization guidance on the interval after stopping everolimus.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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